Overexpressed LAPTM4B-35 is a risk factor for cancer recurrence and poor prognosis in non-small-cell lung cancer

// Fanming Kong 1 , Fangfang Gao 2 , Jun Chen 1 , Yiyu Sun 1 , Ying Zhang 1 , Honggen Liu 1 , Xiaojiang Li 1 , PeiYing Yang 1 , Rongxiu Zheng 2 , Geli Liu 2 and Yingjie Jia 1 1 Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China 2 Department of Pediatrics, Tianjin Medical University General Hospital, Tianjin, China Correspondence to: Yingjie Jia, email: // Keywords : lung cancer, non-small-cell lung cancer, LAPTM4B-35, cancer recurrence, prognosis Received : April 16, 2016 Accepted : June 13, 2016 Published : July 28, 2016 Abstract Background: The expression levels and clinical significances of Lysosomal-associated protein transmembrane-4β-35 (LAPTM4B-35) protein are unknown in the non-small-cell lung cancer (NSCLC). This study aimed to explore the expression and prognostic value of LAPTM4B-35 in NSCLC patients. Methods: The clinicopathological and survival data of 107 NSCLC patients who received radical surgery from 2007 and 2011 were reviewed. The LAPTM4B-35 expression of the paired tumors and adjacent normal specimens were detected, and the association between LAPTM4B-35 and clinical variables was explored. Kaplan-Meier analysis and Cox regression (Proportional hazard model) were performed to investigate the prognostic significance for NSCLC. Results: LAPTM4B-35 was over expressed in NSCLC tissues. The elevated LAPTM4B-35 expression was associated with cancer recurrence ( P = 0.031). The 5-year median OS and PFS were significantly worse in the LAPTM4B-35 overexpressed group. Multivariate Cox analysis showed that LAPTM4B-35 over-expression was an independent factor for OS and PFS in NSCLC( P = 0.018, P = 0.026, respectively). Conclusions: The o verexpressed LAPTM4B-35 was an independent prognostic biomarker for NSCLC, which could predict cancer recurrence and poor over survival. And that may be applied as potential target for NSCLC treatment.