Additional file 3: Figure S1. of Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma

A, The expression of STAT3 and pSTAT3 protein in five HNSCC cell lines examined by Western blot. B, Expression of CDK5 and EMT markers in relation to the status of lymph node metastasis of HNSCC tissues. C, Ectopic overexpression of CDK5 in Hep-2 and Tca8113 cells and resulting revert of EMT after miR-21 silencing or WP1066 treatment. D, Expression of CDK5 and EMT markers in mouse xenografts tissues after WP1066 or asON treatment. E, Expressions of EMT markers after CDK5 plasmid transfection in Tca8113P160 cells. F, Induction of tumor cell motility and EMT after ectopic CDK5 overexpression in transwell assay in Tca8113p160 cells. G, Induction of tumor cell motility and EMT after ectopic CDK5 overexpression in scratch assay in Tca8113p160 cells. (JPG 16931 kb)