New disease marker

Cancer, provides a marker for cancer metastasis and bone diseases, cancer, provides a detection method and kit for diagnosing bone disease. Also it provided cancer, osteoarthritis, rheumatoid arthritis, a pharmaceutical for the prevention and treatment of osteoporosis. Has expressed C0126 in mesenchymal stem cells are useful as gastric cancer marker since expression in gastric cancer is increasing. Further, osteoarthritis since C0126 has a chondrocyte differentiation-inducing activity and are useful as rheumatoid arthritis markers. Further, C0126 polypeptide, a polynucleotide encoding the polypeptide, an antibody against the polypeptides are useful in screening for substances that modulate the chondrogenic differentiation-inducing activity. Substances obtained by the screening is useful as a pharmaceutical, gastric, is useful as a preventive or therapeutic agent for osteoarthritis and rheumatoid arthritis.