Cerebral Microbleeds in an Acute Ischemic Stroke as a Predictor of Hemorrhagic Transformation

: Background Cerebral microbleeds are small, round hypointensities of <10 mm in diameter, evident on T2* gradient-recall echo (GRE) or susceptibility-weighted (SWI) magnetic resonance imaging (MRI) sequences. Objective In this study, our objective was to determine the number and location of cerebral microbleeds in ischemic stroke and to identify the predictive role of microbleeds for hemorrhagic transformation. Materials and methods This was a retrospective cohort study. Microbleeds were visually rated on SWI scans of patients who presented with an ischemic stroke and had an SWI scan within 24 hours of onset and a computed tomography (CT)/MRI scan during follow up. Microbleeds were graded as Grades I-IV. Results Out of 575 stroke patients, 121 did not have an SWI scan and 336 had no follow-up scan. A total of 118 patients were included for a final analysis (75 males, 43 females) out of which 30 had a hemorrhagic transformation. Most microbleeds were in the parietal region (n=46) with 50% transformation (p-value <0.001). The size and grade of microbleeds had a statistical association with hemorrhagic transformation with p-value 0.001 and p-value <0.001, respectively; 33% of patients with Grade 3 microbleeds aging 55-65 years had transformations. Of the patients, 93.3% with Grade 4 microbleeds had a hemorrhagic transformation. 30% of transformations were detected in the first 24 hours while 30% were detected during the first week. Age, gender, comorbidity, and anticoagulant use had no statistical association of conversion of microbleeds into hemorrhagic transformation. Conclusion Microbleeds detected on an SWI scan is a relevant and accurate predictor of hemorrhagic transformations in acute ischemic infarcts and should be added to MRI stroke protocols.