ОЦЕНКА ТЯЖЕСТИ УРОДИНАМИЧЕСКОЙ ОБСТРУКЦИИ У ДЕТЕЙ С ВРОЖДЕННЫМ МЕГАУРЕТЕРОМ НА ОСНОВАНИИ ИССЛЕДОВАНИЯ БИОМАРКЕРОВ МОЧИ 1 Краснова Е.И., 1 Дерюгина Л.А., 1 Захарова Н.Б., 2 Федорова И.А. 1 ГБОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского Министерства здравоохранения России», Саратов, e-mail: krasnovasaratov@yandex.ru; 2 Национальный исследовательский Саратовский государственный университет им. Н.Г. Чернышевского, Саратов

We have done the analysis of the urine biomarkers of infl ammation (interleukin-1β, tumor necrosis factor-α, monocyte chemoattractant protein-1), angiogenesis (vascular endothelial growth factor) and fi brogenesis (matrix metalloproteinase-9) in 47 children with congenital nonrefl uxing megaureter. The correlation between the urine level of IL-1β and main laboratory criteria of infl ammation occurred, so IL-1β as an integrative indicator of pyelonephritis activity was appeared. The relation between levels of VEGF and MCP-1 and indicators of renal hemodynamics allowed to consider increased levels of these factors as markers of the ischemia of the renal parenchyma, induced tubulointerstitial infl ammation and fi brosis. The urine level of MMP-9 was strongly correlated with parameters of peristalyic activity of the ureter. The group of children with lower peristalyic activity of the megaureter was signifi cantly different from group with normal ureteral peristalsis by the high urine level of MMP-9. We do not have reliable data about the diagnostic value of determination of the urine level of TNF-α in children with congenital megaureter.