PREPARATION AND ENHANCEMENT OF SOLUBILITY OF LORATIDINE USING SOLID DISPERSIONMETHOD

In the present study Loratidine solid dispersions were formulated. The enhancement of its solubility and dissolution profile is expected to significantly improve its bioavailability and reduce its side effects. Loratidine was mixed with various proportions of excipients showed no colour change at the end of two months, proving no drug-excipient interactions. The precompression blend of Loratidine soild dispersions were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio . The precompression blend of all the batches indicates good to fair flowability and compressibility. Solid dispersions were prepared with various concentrations of carriers, the prepared solid dispersions were compressed into tablets. The formulated tablets were evaluated for various quality control parameters. The tablets were passed all the tests. Among all the formulations F1 formulation containing, Drug and Peg 4000 in the ratio of 1:0.5 showed good result that is 94.95 % in 50 minutes. As the concentration of polymer increases the drug release was decreased. While the formulations containing PEG 6000 showed less release. Hence from the dissolution data it was evident that F1 formulation is the better formulation. Â