Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men

Background and Objectives: Single dose regimens have advantages in the treatment of STD. Azithromycin has unique pharmacokinetics that may make single dose regimens feasible. Treatment with a single 1 g dose of azithromycin was compared to 100 mg doxycycline twice daily for seven days. Study Design: This was a randomized third-party blinded study on 183 male patients, 176 of whom could be evaluated for efficacy. Results: Chlamydia trachomatis was cultured from 148 patients, 79 receiving azithromycin and 69 receiving doxycycline. Six patients receiving azithromycin had positive cultures on follow-up, four were known to have had sexual intercourse with infected partners