pH reversible response mesoporous silicon oxide composite medicament-carrying system, preparation method thereof and application thereof

The present invention discloses a reversible pH-responsive mesoporous silica composite drug preparation and application system. Firstly sol - gel mesoporous silica nanoparticles Method. And then nano-mesoporous silica magnetic particle surface, respectively, a three-aminomethyl ethane and 4-carboxybenzaldehyde modified, thereby generating a pH-sensitive triaza adamantyl radical reaction under weakly alkaline environment so that the magnetic nanoparticles in the pores of the silica surface covered mesoporous, reversible pH-responsive to give mesoporous silica complex drug system of the invention. The present invention is a reversible pH-responsive mesoporous silicon oxide composite system drug, as a drug, or a carrier protein genes, not only has excellent biocompatibility and good magnetic targeting, pH responsive and to achieve pulsatile release.