Residual fatigue in Guillain-Barré syndrome is related to axonal lossAuthor Response

Editors' Note: Cuetter describes his experience with residual fatigue in Guillain-Barre syndrome, supporting the findings of Drenthen et al. This subclinical fatigue is related to axonal loss. Friedman critiques some of the deductions by the authors who studied the effect of amantadine withdrawal in the AMANDYSK trial. He believes that some of their observations in regard to fatigue and apathy may be related to the placebo effect. The authors respond. —Chafic Karam, MD, and Robert C. Griggs, MD Drenthen et …