Aβ-related cerebral amyloidangiopathy
2004
Cerebral amyloid angiopathy is due to β-protein
accumulation in the vessel walls and occurs in normal aging,
Alzheimer’s disease and hereditary cerebral hemorrhage with
amyloidosis. It causes intraparenchimal and subarachnoid
bleeding with hemosiderin deposits and multiple infarcts
presenting with headache, stroke and epilepsy. Such lesions may
contribute to cognitive impairment. So far, no therapy is
available. In future, amyloid in the vessel wall might be
addressed by amyloid disaggregating drugs and amyloid
antibodies.
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