Impact of Non-Standardized Dosage of Aspirin on High Risk Patients with Cardiocerebrovascular Diseases

Objective To investigate the impact of non-standardized dosage of aspirin on high risk patients with cardiocerebrovascular diseases.Methods Totally 456 outpatients,who regularly receive asprin 40-150 mg/d,from Beijing Anzhen Hospital and community health service centers from June to December of 2007 were enrolled.Of which 275 patients who received asprin ≥75 mg/d were taken as standard group and 181 patients who received asprin 75 mg/d were taken as non-standard group.The platelet aggregation rate and its influential factors were analyzed.Results The platelet aggregation rates induced by arachidonic acid(AA) and adenosine diphosphate(ADP) were(11±3)%,(70±11)% respectively in standard group;and(22±6)%,(73±9)% respectively in nonstandard group(P0.01).The abnormal rates of platelet aggregation induced by AA and AD were 12.73%,52.00% respectively in standard group;and 25.41%,64.64% respectively in nonstandard group(P0.01).Logistic regression analysis showed that,for abnormal platelet aggregation,female,overweight and smoking were independent risk factors in non-standard group,and smoking was independent risk factor in standard group.Conclusion The high risk patients with cardiocerebrovascular diseases should taken aspirin of standardized dosage to inhibit platelet aggregation properly,and thus to reduce death induced by cardiocerebrovascular accidents.