Serrated polyposis syndrome associated with long-standing inflammatory bowel disease
2017
Inflammatory bowel disease (IBD) patients are at an increased
risk of developing colorectal cancer (CRC), which is thought to
develop via the adenoma-carcinoma pathway. Since the discovery
of the serrated carcinogenesis pathway and serrated polyposis
syndrome (SPS), the incidence of carcinomas arising from serrated
lesions in IBD patients has increased. We report three cases of
long-standing IBD patients with associated serrated polyposis
syndrome. At present, the pathophysiology of serrated lesions in
IBD patients is not fully understood and there is a lack of strong
evidence to confirm whether the manifestation of both conditions
represents an increased risk of developing cancer. Therefore, more
accurate surveillance guidelines are needed and are being actively
investigated at present
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