Dihydropyrazolopyrimidine Inhibitors of KV1.5 (IKur)

Wayne Vaccaro,Tram Huynh,John Lloyd,Karnail S. Atwal,Heather Finlay,Paul Levesque,Mary Lee Conder,Tonya Jenkins-West,Hong Shi,Lucy Sun

Dihydropyrazolopyrimidine Inhibitors of KV1.5 (IKur)

2008

Wayne Vaccaro
Tram Huynh
John Lloyd
Karnail S. Atwal
Heather Finlay
Paul Levesque
Mary Lee Conder
Tonya Jenkins-West
Hong Shi
Lucy Sun

Abstract A series of dihydropyrazolopyrimidine inhibitors of K V 1.5 ( I Kur ) have been identified. The synthesis, structure–activity relationships and selectivity against several other ion channels are described.

Keywords:

Potassium channel
Structure–activity relationship
Ion channel
Stereochemistry
Chemistry
tumor cells

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