Changes in mitotic behavior of a cell culture caused by sensitins

A study of the effect of three types of lyophilized preparations of sensitins on human amnion cell cultures showed an increase in the number of pathological mitoses, arrest of division in metaphase, and agglutination of chromosomes which were not present in the control. These changes indicate a harmful action of these preparations on chromosomes and on the achromatic spindle and, in the author's opinion, they characterize the toxic properties of sensitins.