PROFIL DE SENSIBILITE DES SOUCHES DE SPHINGOMONAS PAUCIMOBILIS ISOLEES DE DIVERS PRODUITS PATHOLOGIQUES A L’HOPITAL DE L’AMITIE SINO-GUINEENNE KIPE/ CONAKRY (GUINEE)

RESUME Cette etude retrospective avait  pour objectif de determiner les profils de sensibilite aux antibiotiques des  souches de Sphingomonas paucimobilis isolees  de divers produits pathologiques de 16 patients (urines, spermes, secretions vaginales, liquide pleural, selles et liquide d’ascite). Apres 24 heures de cultures sur milieux geloses, les identifications bacteriennes et les antibiogrammes ont ete realises a l’automate Vitek 2 Compact 15. Le sexe feminin etait predominant avec un sexe-ratio Male/Femelle (7/9) = 0,77. L’âge moyen des patients etait de 55,25 ans avec les extremes de 21 et 83 ans. Les antibiogrammes ont montre que la majorite des souches etaient sensibles a l’amoxicilline/acide clavulanique (87,50%), la piperacilline/tazobactam (93,25%), la cefalotine (68,75%), la cefoxitine (56,25%), le cefotaxime (81,25%), l’imipeneme (93,75%), l’amikacine (93,75%), la gentamicine (93,75%), la tobramycine (93,75%), la ciprofloxacine (62,50%), l’ofloxacine (52,25%). La sensibilite des souches a la ceftazidime etait seulement de 43,75% contre 50% de resistance et une sensibilite intermediaire de 6,25%. En outre, 56,25% des souches etaient resistantes a l’ampicilline  et 68,75% a l’acide nalidixique. Par ailleurs la souche 15 isolee du liquide d’ascite a montre une multiresistance particuliere a tous les antibiotiques testes (14/17) a l’exception de la ciprofloxacine, l’ofloxacine et l’acide nalidixique. Nos resultats ont montre que Sphingomonas paucimobilis est devenu un pathogene emergent implique dans diverses infections bacteriennes et capable d’acquerir une multiresistance a de nombreuses familles d’antibiotiques en Guinee. Mots cles : Sphingomonas paucimobilis , antibiotiques, sensibilite, Hopital Kipe, Conakry-Guinee ABSTRACT Antibiotic susceptibility patterns of Sphingomonas paucimobilis isolated in the biomedical Laboratory from different pathological products at the Chinese and Guinean friendships hospital of Kipe/Conakry (Guinea) The aim of this retrospective study was to determine the antibiotic susceptibility patterns of Sphingomonas paucimobilis isolated between 2012 and 2016 from different pathological products: urines, sperm, vaginal secretions, pleural fluid, stools and ascitic fluid. Sphingomonas paucimobilis identification and antibiotic susceptibility tests were done on Vitek 2 Compact 15. Women were predominant and the sex-ratio Male/female (7/9) was 0,77. The mean age was 55,25% ranging from 21 to 83 years old. Most of Sphingomonas paucimobilis isolates were susceptible to amoxicillin/clavulanic acid (87,50%), piperacillin/tazobactam (93,25%), cefalotin (68,75%), cefoxitin (56,25%), cefotaxime (81,25%), imipenem (93,75%), ciprofloxacin (62,50%), ofloxacin (52,25%). Only 43,75% of Sphingomonas paucimobilis were susceptible to ceftazidim while 50% of these isolates were resistant to this antibiotic and 6,25% showed intermediate sensitivity to the same molecule. The majority of the isolates showed a resistance to ampicillin (56,25%) and to nalidixic acid (68,75%). Finally, the Sphingomonas paucimobilis N 15 isolated from ascetic fluid in 83 years old woman showed the highest multiresistance to all the antibiotics tested (14/17) except ciprofloxacin, ofloxacin and nalidixic acid. Our findings showed that Sphingomonas paucimobilis has becoming an emergent bacterial pathogen that is capable to cause infections in human and can be show multiple resistance to numerous antibiotic families in Guinea. Keywords : Sphingomonas paucimobilis , antibiotic,  susceptibility, Kipe Hospital, Conakry-Guinea