Abstract P268: Serum Lipids, Apolipoproteins, and Mortality among Coronary Artery Disease Patients

Background: The proatherogenic effect of LDL cholesterol and antiatherogenic effect of HDL cholesterol have been confirmed in general population. But controversy arises on the protective role of HDL cholesterol and predictive superiority of apolipoprotein (apo)B among CAD patients. Objectives: This study was to identify the association of different lipid measurements with CAD prognosis and compare their prognostic significance. Methods: The study cohort included 1916 CAD patients who were 40-85 years of age. Cox proportional hazards regression models were used to estimate the association of baseline 6 lipid factors (HDL cholesterol, LDL cholesterol, total cholesterol, non-HDL cholesterol, apoA-I, and apoB) and 3 ratios with all-cause and CVD mortality. Results: During a median follow-up of 3.1 years, 147 deaths were recorded, 113 of which were due to CVD. When lipid factors were categorized, HDL cholesterol showed a U-shape association with all-cause and CVD mortality after adjustment for major CVD risk f...