Effect of Exogenous and Endogenous Prostaglandin E upon Gastric Endocrine Function in Dogs

The effects of prostaglandin E2 (PGE2) and indomethacin- induced endogenous PGE deficiency upon basal and postprandial release of gastric somatostatin-like immunoreactivity (SLI), glucagon, and gastrin during the gastric phase of a meal were determined in anesthetized, laparotomized dogs. The infusion of PGE2 (1 μg/kg- min) elicited a sustained rise in antral vein and inferior vena cava plasma SLI levels and a transient SLI rise in the fundic vein. Antral vein and inferior vena cava gastrin decreased significantly during PGE2 infusion, while fundic vein and inferior vena cava glucagon rose significantly. Indomethacin infusion (2 mg/kg-h) elicited a significant decrease in basal SLI levels in the fundic and antral veins and in the inferior vena cava plasma and a significant increase in basal antral vein gastrin levels, but no change in basal inferior vena cava gastrin or in basal fundic vein or inferior vena cava glucagon levels. The effects of PGE2 infusion upon postprandial SLI, gastrin, and glucagon var...