The recording of monophasic action potentials with fractal-coated iridium electrodes in humans.

The present study was designed to evaluate the feasibility of the recording of monopha-sic action potentials (MAP) with fractal-coated iridium electrodes in a clinical setting. In 18 patients who underwent an electrophysiological study for various arrhythmias, we performed MAP recordings with both 1,3-mm2 and 6-mm2 tip surface area fractal-coated iridium and standard silver-silver chloride (Ag/AgCl) electrodes in the high right atrium and two ventricular positions. Amplitude and MAP duration at 90%, 50%, and 25% of repolarization were calculated during steady-state pacing at 600, 500, and 400 ms cycle lengths with extrastimuli application. Morphology comparisons of MAP signals recorded with both types of electrodes were performed by regression analysis using 5% of the repolarization segments of the MAP trajectory. Differences between MAP duration at 90%, 50%, and 25% of repolarization recorded with fractal-coated and Ag/AgCl electrodes were statistically insignificant. Amplitude values recorded with 6-mm2 tip electrodes were significantly smaller than those recorded with Ag/AgCl electrodes for all comparisons. During steady-state pacing, the correlation coefficients between Ag/AgCl and fractal-coated 1.3-mm2 and 6-mm2 tip electrodes were within the range of 0.93–0.999 and 0.87–0.999, respectively. The correlation of MAP amplitude and duration at 90%, 50%, and 25% of repolarization following the ex-trastimulus S2, recorded with both types of electrodes, was significantly weaker for right atrial recordings (r value range 0.78–0.92) as compared to ventricular recordings (r value range 0.92–0.99). The MAP sensing features of fractal-coated iridium and Ag/AgCl electrodes are comparable. The best results for recording of MAPs with fractal-coated electrodes can be achieved with small surface area tip electrodes.