Increased hepatic glucose production and decreased hepatic glucose uptake at the prediabetic phase in the Otsuka Long-Evans Tokushima Fatty rar model

Abstract To investigate the time course of the hepatic glucose metabolism in non—insulin-dependent diabetes (NIDDM), we measured hepatic glucose production (HGP) and first-pass uptake of portal glucose infusion by the liver (HGU) using dual-tracer methods in a NIDDM model, Otsuka Long-Evans Tokushima Fatty (OLETF) rats, and in normal controls, Long-Evans Tokushima Otsuka (LETO) rats, at 8, 14, and 28 weeks of age (n = 5, respectively). The fasting plasma glucose level in OLETF rats was significantly higher than in LETO rats at 28 weeks of age (8.9 ± 1.7 v 6.3 ± 0.4 mmol/L, P v 9.4 ± 1.8 mg · kg −1 · min −1 , P v 7.1 ± 1.3 mg · kg −1 · min −1 , P v 2.3 ± 0.5, P v 1.4 ± 0.3, P v 1.4 ± 0.3 mg · kg −1 · min −1 , P