New Coumarin and Bioactive Constituents of Chionanthus retusus

2021 
A new coumarin derivative, 7-O-methylparamicoumarin A (1), has been isolated from the roots of Chionanthus retusus, together with seven known compounds. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (3), quercetin (4), and apigenin (5) exhibited cytotoxicities with IC50 values of 13.69 ± 1.10, 10.41 ± 0.79, and 12.25 ± 0.91 μM, respectively, against DLD-1 cell line. Luteolin (3), quercetin (4), and apigenin (5) also exhibited cytotoxicities with IC50 values of 15.35 ± 1.24, 13.52 ± 0.87, and 19.48 ± 1.26 μM, respectively, against CCRF-CEM cell line. In addition, kaempferol (2), apigenin (5), 3,3′,5,5′,7-pentahydroxyflavanone (6), and oleuropein (8) showed potent inhibition with IC50 values of 24.84 ± 1.95, 27.18 ± 1.82, 25.18 ± 2.07, and 28.14 ± 1.66 μM, respectively, against LPS-induced NO generation.
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