Structure—Activity Relationship Studies of Chloromethyl Ketone Derivatives for Selective Human Chymase Inhibitors.
2010
Based on the SAR study of a classical chloromethyl ketone derivative, Z-PheCH2Cl 1, a series of compounds were synthesized. Among all the derivatives, compound 21 was found to be a potent human chymase inhibitor with no inhibitory activity against human leukocyte cathepsin G.
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