Structure—Activity Relationships of New 2‐Acylamino‐3‐thiophenecarboxylic Acid Dimers as Plasminogen Activator Inhibitor‐1 Inhibitors.

It is shown that compounds possessing bulky or/and hydrophobic substituents on both the thiophene rings exhibit potent PAI-1 inhibitory activities irrespective of the positions of the substituents.