Micelle Formation of Coenzyme Q10 with Dipotassium Glycyrrhizate Using Inclusion Complex of Coenzyme Q10 with γ-Cyclodextrin B

Micelles can be formed from coenzyme Q₁₀ (CoQ₁₀) and dipotassium glycyrrhizate (GZK₂) by using an inclusion complex of CoQ₁₀ with γ-cyclodextrin (γ-CD). The mechanism of micelle formation was kinetically investigated. Adding GZK₂ to a supersaturated solution of the CoQ₁₀/γ-CD inclusion complex led to a linear increase in the solubility of CoQ₁₀ due to the formation of micelles of CoQ₁₀ when the molar ratio of GZK₂/γ-CD increased to ∼1.6, after which the concentration remained constant. The equilibrium constant K for micelle formation was 0.68 (−) and the ratio of GZK₂ to CoQ₁₀ was 1. These results suggest that the formation of CoQ₁₀ micelles with GZK₂ might proceed via the displacement of CoQ₁₀ by GZK₂ in the γ-CD cavity followed by the formation of CoQ₁₀ micelles.