Treatment for Factor V Leiden, Stuck Between a Rock and a Hard Place: A Case Report and Review of Literature

Factor V Leiden is a genetically inherited disorder which causes hypercoagulable state that accounts for 40-50% of cases of thrombophilia. The diagnosis of factor V Leiden thrombophilia is made either by using a coagulation screening test or by DNA analysis of F5, which encodes the factor V protein. Management of this disorder can be challenging due to the fact that the current treatment regimen can place the patient in a bleeding state with potential hazardous effects. We are reporting the case of a 49-year-old man who presented with shortness of breath diagnosed with multiple episodes of pulmonary embolisms, DVT and factor V Leiden deficiency treated with oral anticoagulants again presented with dizziness and upper GI bleed. J Hematol. 2014;3(2):43-45 doi: http://dx.doi.org/10.14740/jh149w