AN OVERVIEW ON VARIOUS APPROACHES USED FOR SOLUBILIZATION OF POORLY SOLUBLE DRUGS

The aim of this review is to improve the solubilization of poorly soluble drugs by using various approaches. The solubility of a solute is the maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature. In the other words the solubility can also define as the ability of one substance to form a solution with another substance . Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown and dissolution of drug is the rate determining step for oral absorption of the poorly water soluble drugs, which can subsequently affect the in vivo absorption of drug. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules Currently only 8% of new drug candidates have both high solubility and permeability. The mechanism of solubilisation involves the breaking of inter-ionic or intermolecular bonds in the solute, the separation of the molecules of the solvent to provide space in the solvent for the solute, interaction between the solvent and the solute molecule or ion. The solubility depends on the physical form of the solid, the nature and composition of solvent medium as well as temperature and pressure of system. Various techniques available to improve the solubility of poorly soluble drugs by physical and chemical modifications.