[Effects of hemoperfusion on the patients with acute toxication of 2, 4-dinitrophenol].

Objective To explore the management strategies of acute toxication of 2,4-dinitrophenol by hemoperfusion. Methods A total of 14 patients with acute toxication of 2,4-dinitrophenol were admitted on September 14, 2009.And they were divided into severe and mild groups according to the severify of clinical manifestation.All patients in both groups received 2-hour blood perfusion within 2 hour post-admission.Their clinical manifestations, laboratory parameters and 2, 4-dinitrophenol levels were carefully observed before and after each perfusion.And oxygenation, intravenous use of furosemide, corticosteroids and symptomatic therapies were simultaneously given to improve general conditions. Results In serious group, the levels of before and after the first perfusion were 28.21 (15.56-45.23) and 16.11 (10.10-27.52) mg/L (P<0.05), respectively.In both groups,all levels of 2,4-dinitrophenol were significantly reduced before and after each perfusion (all P<0.05).The patients in severe group would get relieved after 3 vs 2 perfusions in mild group.In severe group, there was a remarked decrease in neutrophil and platelet count after perfusion than those in mild group.The liver enzymes and blood lipids in both groups after therapy significantly elevated than those before therapy (all P<0.05). Conclusion Crucial for managing acute toxication of 2,4-dinitrophenol, early hemoperfusion reduces mortality. Key words: Hemoperfusion; 2,4-dinitrophenol; Poisoning