A New And Convenient Synthesis Of Some Substituted Thiohydantoins

Abstract 3-Substituted thiohydantoins (2a-g) were synthesized in satisfactory yields by the reaction of N-substituted thioureas (la-g) with chloroacetylchloride in the presence of triethylamine under reflux in dioxane. S-Alkylated products (7, 8) were obtained from the reaction of 3-p-tolyl -thiohydantoin (2d) with p-nitrobenzylchloride and 3-phenyl-5-chloromethyl-I,2,4-oxadiazole.