A stepwise 2'-hydroxyl activation mechanism for the bacterial transcription termination factor Rho helicase.
2009
The bacterial transcriptional termination factor Rho is a hexameric helicase that tracks along RNA and dissociates DNA-RNA hybrids. Here the activity of Rho is examined using nucleotide analog interference mapping, revealing that the helicase takes large, 7-nt steps, triggered by contacts with 2′OH in the tracked RNA substrate.
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