Response of rabbits with implanted Brown-Pearce tumor to vaccination with live tularemia vaccine

The reactivity of rabbits with an implanted Brown-Pearce tumor was studied following their vaccination with live tularemia vaccine. Formation of immune agglutinins and allergic reactions were investigated both in healthy rabbits and in animals with an implanted tumor. The study of these reactions demonstrated an intensified reactivity of the experimental animals during the first stage of tumor development; its marked depression up to the time marking the development of anergy was noted during metastasis.