Динамика маркеров гемостаза в условиях гемодиафильтрации у детей при тяжелом сепсисе

This study investigated the influence of renal replacement therapy (hemodiafiltration) on basic parameters of hemostasis in 41 children (4 months 17 years old) with severe sepsis and multiple organ dysfunction. Diferential diagnosis of initial coagulopathies revealed follow: the incidience of syndrome DIC was 93%, and 7% liver coagulopathy. We found hemodiafiltration led to normalizing of serum coagulating and antifibrinolytic activity and basic parameters of hemostasis. These changes of hemostasis depends on age of child and stage of syndrome DIC. Infants with consumption coagulopathy and insufficient liver function showed the normalizing of hemostasis after 48 hours. Older children restored parameters of hemostasis nduring 24 hours. All children with coagulating variant of syndrome DIC showed hemostasis normalizing after 24 hours. Mortality was 20% in infants group and 5?5% among older children.