Острофазовые белки плазмы крови в процессе подготовки к панкреатодуоденальной резекции при раке головки поджелудочной железы

Dynamics of general activity oftrypsin proteinases, total kallikrein and universal blood plasma inhibitors during preparation of patients with cancer of the pancreatic head (CPH, Т2-4N0M0) for pancreaticoduodenal resection (PDR) was studied. After each of the two phases of preparatory procedures, an increase in inhibitory capacity of blood was observed on day 1 only with maintenance and activation of proteolysis. Significant decrease in proteinase activity in blood plasma developed by the end of the second week after automated plasmapheresis (APP). Proteinase-inhibitor imbalance was restored on day 30 after APP and immediately before PDR. Complications after PDR can be associated with enzyme-enzyme and enzyme-inhibitor imbalance in the system of trypsin-like proteinases. Taking into account the above results, in planning the preparatory procedures and PDR time one should consider period not later than day 10–14 after APP.