Effects of resistance training on testosterone metabolism in younger and older men

Abstract This study investigated the effects of resistance training (RT) on the metabolism of testosterone (T) in younger (n = 5, 28 ± 3 yrs.) and older (n = 8, 70 ± 2 yrs.) men. Experimental heavy resistance exercises (5 × 10RM leg presses) were performed before and after a 12-month of RT. No age differences were found in the production or metabolic clearance rate of T (determined by stable isotope dilution method), skeletal muscle androgen receptor content or serum LH concentrations due to acute or chronic RT. The T production capacity response to gonadotropin stimulation and the concentrations of the urinary T metabolites (androsterone and etiocholanolone) were lower in the older compared to younger men (p