HEPATOPROTECTIVE EFFECT OF THE METHANOLIC EXTRACT OF WHOLE PLANT OF BORRERIA ARTICULARIS ON CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS

The hepatoprotective activity of methanolic extract of Borreria articularis (L.F) F.N. Willams: (Rubiaceae) at doses of 250 mg/kg and 500 mg/kg were evaluated by carbon tetrachloride (CCl4) intoxication in rats. The toxic group which received 25%CCl4inolive oil (1 ml/kg) per oral (p.o), alone exhibited significant increase in serum ALT, AST, ALP, TBlevels. It also exhibited significant (P<0.001) decrease in TP and ALB levels. The groups received pretreatment of Borreria articularis at a dose of 250 and 500 mg/kg b.w.p.o. had reduced the AST, ALT, ALP and TB levels and the effects were compared withstandarddrug(Silymarin100mg/kgb.w.p.o).Thetotal protein (TP) and albumin (ALB) levels were significantly increased in the animalsreceived pretreatment of the extract at the moderate and higher dose levels and the histopathological studies also supported the protective effect of the extract.