Hepatoprotective activity of analogs of cinnamic acid

: The hepatoprotective activity of 16 derivatives of +hydroxycinnamic acids was studied on the model of acute tetrachloromethane-induced hepatitis. The effects of the agents administered in doses of 5, 15, and 30 mg/kg were compared with those of silibor, vitamin E and flamine. The studied compounds were shown to possess the bile-expelling, antioxidant and membrane-protective effects being superior in some cases to similar effects of reference drugs. The structure-activity relationship was established.