Abstract 10973: Sulfenylation of Copper Importer CTR1 Drives Redox-Dependent VEGFR2 Internalization and Angiogenesis Required for Reparative Neovascularization

Archita Das,Dipankar Ash,Youngmee Kim,Sudhahar Varadarajan,Silvia Leanhart,Lianying He,Jack H. Kaplan,Tohru Fukai,Masuko Ushio-Fukai

Abstract 10973: Sulfenylation of Copper Importer CTR1 Drives Redox-Dependent VEGFR2 Internalization and Angiogenesis Required for Reparative Neovascularization

2018

Archita Das
Dipankar Ash
Youngmee Kim
Sudhahar Varadarajan
Silvia Leanhart
Lianying He
Jack H. Kaplan
Tohru Fukai
Masuko Ushio-Fukai

Introduction: Reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, play an important role in angiogenesis; however, their relationship in VEGF-induced angiogenesis in endothel...

Keywords:

Neovascularization
VEGF receptors
Angiogenesis
Internal medicine
Redox
Reactive oxygen species
Copper
Cardiology
Cell biology
Internalization
Medicine
Signal transduction

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