Tuberculosis subunit vaccine containing compound adjuvant

The invention relates to a tuberculosis subunit vaccine which takes Ag85b, ESAT6, CFP10 and HspX protein as antigen components of the vaccine and takes Al (OH)3 and BCG-CpG-DNA (DNA extract of BCG) as a compound adjuvant. By taking Ag85b, ESAT6, CFP10 and HspX protein as the antigen components of the vaccine, the vaccine not only can prevent the infection from the tubercle bacillus, but also can prevent the tuberculosis of the person infected with tubercle bacillus and has the function of preventive treatment. By taking Al (OH)3 and BCG-CpG-DNA as the compound adjuvant, the vaccine can effectively improve the immune effect of the vaccine, promotes the T cell proliferation, adjusts the dynamic balance of Th1 and Th2, and leads the T cell immunity to transform towards Th1 predominant response.