Comparison of F-18 FET-PET with F-18 FDG-PET for biopsy planning of non-contrast-enhancing gliomas

Objective: The management of non-contrast-enhancing brain tumours largely depends on biopsy, which allows a differentiation of low-grade gliomas (LGG) from high-grade gliomas (HGG). The aim of this study was to compare positron emission tomography using 2-[18F]-fluoro-2-deoxy-d-glucose (FDG-PET) and O-(2-[18F]-fluoroethyl)-l-tyrosine (FET-PET) in terms of providing target regions for biopsies.