Supported l-proline on zirconium phosphates methyl and/or phenyl phosphonates as heterogeneous organocatalysts for direct asymmetric aldol addition
2011
Abstract Zirconium phosphates methyl and/or phenyl phosphonates-supported l -proline have been prepared as amorphous solids by precipitation of (4 R )-4-(phosphonooxy)- l -proline, methyl and/or phenyl phosphonic acid with ZrOCl 2 . The supported l -proline catalysts were tested on the direct asymmetric aldol addition of cyclohexanone to p -nitrobenzaldehyde in DMF/H 2 O (9:1) and in sole water. The hydrophobic groups on solid surface favor reagents’ diffusion toward proline chiral moiety increasing the catalytic activity of supported l -proline. High diastereoselectivity ( anti/syn up to 94:6) and high enantiomeric excess up to 97% have been obtained.
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