CF3CO2H-Catalyzed Synthesis of 3-Alkynylpyrrole Derivatives and Their Controlled Reduction.
2021
A transition-metal-free methodology employing nitroenynes and enaminones has been developed to access 3-alkynylpyrrole derivatives. This mild cyclization reaction might proceed through the nucleophilic addition, intramolecular cyclization, and the subsequent elimination processes. The protocol features a broad substrate scope, good selectivity, and functional group tolerance. Notably, the advantage of this method is also highlighted by the controlled reduction to generate alkenyl- or alkylpyrrole derivatives in good to excellent yields.
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