Insulin receptors in the developing fetal lung

Abstract Fetal lung insulin receptor numbers and affinities were studied in rat pregnancies from 15 to 22 days gestation. Insulin receptor binding capacities were found to increase six-fold from approximately 100 fmoles insulin bound/mg lung DNA at 15 days gestation to approximately 600 fmoles bound/mg DNA at 22 days gestation. However, the affinity constants of the receptors were unchanged during this same period (high affinity, 1.9 ± 0.4 S.E. and low affinity, 0.03 ± 0.01 S.E.). The results suggest that the lung may become increasingly more sensitive to insulin as development progresses.