The protective effect of oxygenated perfluorocarbons (PFCs) on intestinal ischemia reperfusion injury (I/R) in rabbits.

Objective: To evaluate the effect of intraluminal administration of oxygenated perfluorocarbons (PFCs) on small intestine’s viability in an experimental model of acute ischemia-reperfusion (I/R).Methods: Twenty rabbits were divided in four groups: sham-operated controls (group A), acute I/R (group B), acute I/R plus infusion of PFCs 30 min before ischemia (group C), and acute I/R plus infusion of PFCs 30 min before reperfusion (group D). Malondialdehyde (MDA) tissue levels and d-lactate blood samples were taken. All tissue sections were examined under light microscope.Results: Mean MDA levels in group A: 1.79 ± 0.97 at 0 min, 2.25 ± 1.76 at 120 min and 3.70 ± 1.76 nmols/g at 180 min. Group B: 2.60 ± 0.58 at 0 min, 4.20 ± 0.58 at 120 min and 5.48 ± 2.01 at 180 min. Group C: 1.54 ± 0.85 at 0 min, 1.14 ± 0.37 at 120 min and 0.59 ± 0.35 at 180 min. Group D: 2.12 ± 0.62 at 0 min, 3.97 ± 0.70 at 120 min and 2.32 ± 0.37 at 180 min (p < 0.05). Mean d-lactate levels in group A: at 0 min 36.45 ± 1.99, at 120 min 39...