Норадреналин в ишемическом прекондиционировании миокарда

AIM: To determine the effects of two staged ischemic preconditioning on myocardial noradrenaline in prolonged ischemia and reperfu-sion. METHODS: Thirty-two male Wistar rats anesthetised with urethane were randomly divided into 2 groups: group 1 (ischemic preconditioning group, n=16), and group 2 (control, n=16). Myocardial interstitial noradrenaline levels were measured using a microdialysis technique. Ischemic preconditioning was elicited by a two episodes of 5 min ischemia and 10 min reperfu-sion. The intermittent occlusions were followed by prolonged occlusion (60 min) and reperfusion (60 min). RESULTS: An increase in interstitial noradrenaline was observed by 10 min of prolonged ischemia in group 2, and by 15 min in group 1. After 30 min of myocardial ischemia there was a significant difference between groups (p