Stereoselective total synthesis of (-)-galantinic acid and 1-deoxy-5-hydroxysphingolipids via Prins cyclization

Abstract The stereoselective total synthesis of (-)-galantinic acid 1 and 1-deoxy-5-hydroxysphingolipids 4 is described via Prins cyclization protocol followed by reductive ring opening sequence of substituted pyrenol derivative 6. Both the target molecules were synthesized using common synthetic intermediate epoxide 5. Besides, we also proposed the pathways to achieve other structural analogues using common intermediates.