NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies

Corinna Lau,Martin B. McAdam,Grethe Bergseth,Algirdas Grevys,Jack-Ansgar Bruun,Judith K. Ludviksen,Hilde Fure,Terje Espevik,Anders Moen,Jan Terje Andersen,Tom Eirik Mollnes

NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies

2019

Corinna Lau
Martin B. McAdam
Grethe Bergseth
Algirdas Grevys
Jack-Ansgar Bruun
Judith K. Ludviksen
Hilde Fure
Terje Espevik
Anders Moen
Jan Terje Andersen
Tom Eirik Mollnes

ABSTRACTThe mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used cli...

Keywords:

Eculizumab
Virology
Antibody
Mechanism of action
Immunology
Biology
Effector
Hybrid antibody
Recombinant DNA
therapeutic antibody
effector functions

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