S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability

Vascular endothelial (VE)-cadherin is S-nitrosylated and phosphorylated by 1-O-alkyl-2-acetyl-sn-glycero-3-phospho-choline (PAF) at the endothelial cell junction. Importantly, we advance the concept that S-nitrosylation activity is necessary for VE-cadherin phosphorylation, which regulates its internalization. Our work supports the key function of S-nitrosylation in the complex dynamics of junctional proteins in the regulation of microvascular permeability.