An efficient synthesis of (S)-5-hydroxymethyl-2(5H)-furanone
1987
Abstract A three step synthesis of the title compound 1a from D-ribono-1,4-lactone in 48% yield is described. The concept centers on a novel NaHSO 3 -induced trans -Br-OAc elimination of the readily prepared bromo-acetate mixture 3a,b to the corresponding butenolides 1e and 1f , the former of which, on hydrolysis and purification, yields pure 1a .
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