Formulation and Evaluation of Orodispersible Tablets of Metoprolol Tartrate with Natural and Synthetic Superdisintegrants

The main objective of this study was to formulate and evaluate the oro dispersible tablets of metoprolol tartrate with natural and synthetic superdisintegrants. Various formulations were prepared by direct compression using different percentages of natural superdisintegrant i.e. locust bean gum and synthetic superdisintegrants namely sodium starch glycolate, crospovidone, and croscarmellose sodium ranging from 3%-12%. The drug and excipients compatibility study was performed by FTIR and the study revealed no interaction between drug and excipients. The blend of all formulations were evaluated for various precompression parameters like angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio and were found to be satisfactory. The tablets were evaluated for various parameters like weight variation, thickness, and hardness, friability, wetting time, water absorption ratio, disintegration time, content uniformity and in vitro drug release. The disintegration time was found to be 17 seconds for the optimized formulation of Locust Bean Gum 3. The optimized formulation was subjected to stability studies for three months as per ICH guidelines. The formulation was found to be stable with insignificant change in the physical appearance, hardness, disintegration time, drug content and in vitro drug release.