Pulse pressure and pulse pressure index:prediction for and correlation with the severity of coronary artery lesion in patients with coronary artery disease

Objective To investigate the correlation between pulse pressure(PP),pulse pressure index(PPI) and the severity of coronary artery lesion in patients with CAD,and evaluate the significance of PP and PPI in predicting CAD.Methods The data of 9847 patients who had undergone coronary angiography were collected.The positive coronary angiography(stenosed major vessels ≥ 50%) served as a diagnostic standard of CAD.CAD severity was assessed by Gensini score,and the number of stenosed arteries was counted.Relationship between PP,PPI and the severity of CAD was evaluated by both single factor analysis and multivariate binary logistic regression analysis.Results The CAD patients were found to have higher PP(54.63±15.82 vs 49.74±14.27,P < 0.001) and PPI(0.40±0.07 vs 0.38±0.07,P < 0.001).Furthermore,the severity of CAD were associated with increased PP and PPI.Binary logistic regression analysis showed that PPI was a prominent predictor of the CAD(OR=4.921,95%CI 2.241~10.808,P < 0.001).Conclusion The levels of PP and PPI are significantly correlated with CAD;PPI is the most prominent predictor in diagnosis of CAD.