A 3-year follow-up study of enhancing and non-enhancing multiple sclerosis (MS) lesions in MS patients demonstrating clinically isolated syndrome (CIS) using a multi-compartment T2 relaxometry (MCT2) model

Obtaining information on condition of tissue microstructures (such as myelin, intra/extra cellular cells, free water) can provide important insights into MS lesion. However, MRI voxels are heterogeneous in terms of tissue microstructure due to the limited imaging resolution owing to existing physical limitations of MRI scanners. Here we evaluated a multi-compartment T2 relaxometry model and then use it to study the evolution of enhancing (USPIO and gadolinium positive) and non-enhancing lesions in 6 MS patients with CIS characteristics over a period 3 years with 7 follow-up scans post baseline.