Manifestaciones inflamatorias oculares inducidas por el virus del dengue

Dengue infection can produce a wide clinical spectrum of inflammatory manifestations in the eye. Ocular manifestations during the critical period of the disease are more frequently associated with vascular damage induced by the viral protein NS1. Sight-threatening retinal conditions in that period include posterior uveitis and dengue maculopathy. Retinal hemorrhages, edema, vasculitis and exudative retinal detachment are the most frequent presentations of posterior uveitis. SD-OCT and OCTA are tools capable to locate the affected retinal layers and capillary plexus involved in the retinopathy. Neuroophthalmological manifestations although infrequent are an important cause of visual disturbance, inducing ophthalmological inter-consults in hospitalized patients. Available treatments include supportive measures, systemic corticosteroids and intravenous immunoglobulin. There is an urgent need for clinical studies to test drugs known to restore vascular permeability as well as new antiviral drug candidates.